In this fourth white paper of the series, we address frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations. In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. With that said, the challenge that remains with the application of DLS to protein therapeutic formulations is centered around data interpretation. The popularity of DLS within the biopharmaceutical industry is a consequence of its wide working size and extended sample concentration ranges, as well as its low volume requirements. DLS measurements for size distribution and zeta potential were conducted on a Malvern Zetasizer Nano ZSZEN3700 DLS nanoparticle analyzer (London, UK). A Malvern Instruments' Bioscience Development Initiativeĭynamic light scattering (DLS) is an analytical technique used to measure the particle size distribution of protein formulations across the oligomer and sub-micron size ranges of approximately 1 nm to 1 µm. Dynamic Light Scattering technology from Malvern Panalytical offers the following advantages: Accurate, reliable and repeatable particle size analysis in one or two minutes. Herein, we reported a new dynamic light scattering (DLS) immunosensing technology for the rapid and sensitive detection of glycoprotein N-terminal pro-brain natriuretic peptide.
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